Tuberculosis bacteria are like pests that burrow underground and vanish. When pesticides hit, they harden into shells and hide in the soil. They look dead, but later, they erupt and devour everything. A quiet field becomes a feeding ground all over again.
New research published in npj Vaccines shows TB uses similar tricks. The bacteria “play dead” to survive attacks from the immune system. After vaccination, TB changes its behavior to escape destruction. It becomes quiet, stops growing, and hides from immune cells.
Later, the bacteria can wake up and spread inside the host. This reactivation can cause lung disease and infect other people. The tactic helps TB remain the world’s deadliest infectious disease. Each year, TB kills around 1.25 million people worldwide.





