ME/CFS and long-COVID are post-viral illnesses with overlapping symptoms. These include fatigue, brain fog, gut problems, and exercise-related crashes. But the exact cause of these conditions is still not known. This gap limits efforts to create effective treatments.
Researchers now propose a new explanation for how these begin. They believe viral infections damage blood vessel cells called endothelium. This damage can happen directly or through other immune responses.
In certain body areas, these damaged cells may become senescent. Senescent cells stop working properly but still send strong chemical signals in a “zombie-like” state. This occurrence is called the senescence-associated secretory phenotype, or SASP.





