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Scientists have made a surprising discovery that could change antibiotic research. They found a new antibiotic hiding within bacteria already studied for decades. This unexpected find could open a new path for discovering life-saving drugs. It may also become a crucial tool against antimicrobial resistance.

Antibiotic resistance is growing worldwide. A 2023 World Health Organization report showed that one in six common bacteria resisted treatment. This marked a 40% rise since 2018, with resistance increasing by 5 to 15% each year. Such rapid growth makes finding new antibiotics more urgent than ever.

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Tuberculosis remains the world’s deadliest infectious disease, despite being treatable and preventable. It kills about 1.6 million people every year, mostly in low-income countries.

Researchers have developed a new compound called CMX410 that targets tuberculosis bacteria. The compound shuts down a vital enzyme called polyketide synthase 13, or PKS-13. This enzyme helps the bacteria build a protective outer shell.

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Like extra bombs tucked away inside a missile, viruses hidden inside bacteria don’t seem like a great place to find new treatments. However, researchers from Penn State found viral DNA within ancient bacteria that helped them fight viruses. Specifically, the enzyme called PinQ flips a switch on bacterial genes. The result is the generation of proteins that block viruses from infecting bacteria.

By studying this mechanism, researchers may uncover new antiviral drugs and antibiotics. The discovery could also impact industrial microbiology and bioengineering.

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They say to know your enemy. What better way than to see it in atomic detail? Researchers at the University of Queensland achieved this with the yellow fever virus. They captured high-resolution images showing structural differences between vaccine strains and wild strains.

These maps revealed how the two virus types affect the immune system differently. Yellow fever virus, or YFV, is a deadly mosquito-borne disease. It damages the liver and causes fever, jaundice, and internal bleeding. Severe cases can lead to organ failure and death.

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MIT biological engineers found new targets for a better tuberculosis vaccine. They identified specific antigens that may trigger stronger immune responses. These findings could lead to vaccine candidates that protect more effectively. Tuberculosis remains the world’s deadliest infectious disease.

Researchers conducted a large-scale screen of TB proteins to find potential targets. The screening revealed multiple antigens suitable for new vaccine design. From over 4,000 bacterial proteins, scientists pinpointed several highly immunogenic peptides. These peptides caused powerful reactions from T-cells, which fight infections.

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