Some religious traditions teach that world history began 6,000 years ago. Science does not support this exact timeline. But a major shift in human life did happen at that point: farming and livestock domestication began spreading across Eurasia.
New research in Nature shows that more than crops and animals multiplied. Zoonotic pathogens—diseases from animals—first appeared about 6,500 years ago. These infections surged around 5,000 years ago. The rise of pastoral life helped them spread more easily.
Scientists studied ancient DNA to trace disease over time and space. They analyzed samples from 1,313 individuals across 37,000 years. The microbes came from 136 different genera—bacteria, viruses, and parasites. Of these, 3,384 matched known human pathogens.
Thousands of these diseases had never been seen in ancient remains. This study reveals how microbes changed with human culture. It marks a turning point in the long story of human health.





