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Wastewater Surveillance is a Promising Tool for Disease Detection

May 26, 2025 by Lochlan DuVal Leave a Comment

Wastewater is becoming an important tool in disease detection.
Image courtesy of Joseph Russo.

New CDC research shows wastewater sampling can predict outbreaks early. Scientists simulated pathogen monitoring in sewer systems. They found wastewater tracking detects viruses and bacteria before they spread widely.

A separate Nature study simulated wastewater sampling from airplanes. It showed this method detects pandemics two months earlier than current protocols. Researchers suggest monitoring 20 major airports to track new diseases.

How Does Wastewater Surveillance Help Identify Diseases?

Wastewater testing confers many benefits. It is non-invasive and requires no swabbing. It can detect pathogens in preserved land and farms without on-site monitoring. This method helps track diseases like bird flu, which is spreading fast.

Alessandro Vespignani, a health sciences professor at Northwestern, supports wastewater testing. He told The Guardian it works faster than border or hospital screenings. He estimates it can detect viruses two months earlier than other methods.

Wastewater analysis could create a standardized system for sample collection. Standardization would allow easier comparisons between different regions. A global wastewater system could detect new pathogens early.

Past wastewater samples can also reveal when a disease first appeared. The CDC recently used old samples to trace the start of bird flu spread.

What Did the CDC Study Show about Wastewater Surveillance?

The new CDC study found AH5 avian influenza in Oregon wastewater early. Virus samples appeared six weeks before poultry infections were confirmed. Avian flu was also detected seven weeks before it appeared in wild birds.

Researchers reviewed wastewater data from September 2021 to July 2024. They identified 21 avian flu incidents in 12 Oregon communities. The study found 551 bird flu samples from 20 different locations.

Wastewater sampling showed no link between bird flu and poultry outbreaks. It also found no connection to dairy farms or processing facilities. Instead, the virus was most common near wild bird habitats.

Bird flu was first found in U.S. wild birds in 2022. Since then, it has spread widely in birds and some mammals. It has infected over 112 million domestic birds in 49 states.

Researchers found bird flu in U.S. dairy cattle for the first time in March 2024. By December, 718 herds in 15 states were infected. Oregon has not reported infections in dairy cattle or milk contamination.

The study found wild birds likely contributed to bird flu in wastewater. Oregon is part of the Pacific Flyway, a major bird migration path. Over a billion birds follow this route each year.

What Did the Nature Study Show about Wastewater Surveillance?

A recent Nature study suggests airports play a key role in disease spread. However, it also shows how they can be invaluable for early disease detection. Wastewater surveillance has tracked COVID-19, polio, and flu. Monitoring wastewater in aircraft could support a global disease tracking system.

Creating a worldwide wastewater network comes with challenges. Researchers must decide which airports to test and how often to sample. They also need to choose which pathogens to track.

The study used the Global Epidemic and Mobility Model (GLEAM) to simulate outbreaks. GLEAM divides the global population into 3,200 locations linked by air travel. It tracks disease spread using airline data from 4,600 airports.

The model found 20 key airports could detect outbreaks faster than current methods. Researchers selected the busiest international hubs to ensure broad coverage. The study found smaller airports took longer to detect new diseases.

However, testing only 20 airports detected outbreaks 20% slower than global coverage. Surveillance effectiveness varied by region. Europe detected outbreaks faster than Africa. High-traffic airports improved detection because they received more international flights.

The study suggests wastewater monitoring could have detected COVID-19 earlier. The SARS-CoV-2 Alpha variant could have been found two months sooner. A global wastewater system might have helped slow COVID-19’s spread.

Conclusion

Wastewater surveillance is a powerful tool for detecting diseases early. Monitoring airports and sewer systems could improve global outbreak response. A standardized wastewater network might help prevent future pandemics.

Have an upcoming trip? Passport Health offers a wide variety of options to help keep you safe from disease, including vaccines. Call or book online to schedule your appointment today.

Logan Hamilton is a health and wellness freelance writer for hire. He’s passionate about crafting crystal-clear, captivating, and credible content that elevates brands and establishes trust. When not writing, Logan can be found hiking, sticking his nose in bizarre books, or playing drums in a local rock band. Find him at loganjameshamilton.com.

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