Twinrix Vaccination With 250+ travel clinics nationwide, Passport Health is your local leading provider of travel vaccinations and medications. Prepare your health for travel, visit us before you go. What is the Twinrix Vaccine? Hepatitis A Hepatitis B Will I Need Twinrix Booster Shots? What is the Twinrix Vaccine? Twinrix is a vaccine that protects against both the hepatitis A and hepatitis B Virus. Three Twinrix vaccinations are required to complete the series. The second shot is given 30 days after the initial vaccination and the third shot is administered 6 months after the first. As a matter of convenience, Twinrix reduces the number of shots needed to complete both Hepatitis A and B series from 5 to only 3. Hepatitis A Learn more about hepatitis A and the hepatitis A vaccination Hepatitis B Learn more about hepatitis B and the hepatitis B vaccination Will I Need Twinrix Booster Shots? Like the hepatitis A and B vaccines, Twinrix does require booster shots in order to be fully effective. According to Twinrix, one booster is needed at a month and another after six months. Twinrix booster vaccines are not needed in order to travel as the vaccine is effective within two weeks of the first dose. But, they should be given in order to have lifetime immunity to both hepatitis A and B. So, if you are asking yourself, “What travel shots and vaccinations do I need?” or “Where do I get the Twinrix Vaccine?” schedule an appointment with your local Passport Health travel medicine clinic.